Abstract
THE EFFECT OF OCHRATOXIN A ON LIPID PEROXIDATION FROM OCHRATOXIGENIC FUNGI OBTAINED FROM DRIED CASSAVA POWDER GARRI USING AN ANIMAL MODEL.

Agu Georgia Chinemenwa*, Salami Olufunmilayo Olamide, Odusola Kikelomo B.

ABSTRACT

Ochratoxin A (OTA) is a very dangerous Mycotoxins, and hence this study aimed at determining the role of Ochratoxin in the induction of lipid peroxidation. Ochratoxigenic Aspergillus species were isolated from garri sample and re-inoculated into fresh garri to produce Ochratoxin. The extracted pure Ochratoxin A was injected into the rat model at varied concentration of 0.75, 0.81 and 0.90ml/kg weight except for the control group that received no Ochratoxin A. The lipid peroxidation was measured using an assay kit from bio-division incorporation. The result of the study revealed Aspergillus niger has the most prevalent of the isolated Ochratoxigenic fungi 36(50%) followed by Aspergillus carbonarius 36(33.3%) and Aspergillus ochraceus 36(16.7%). The Ochratoxin A was found to significantly affect the weight gained ratio (F= 185.19, 9<0.05) and the feed weight gained ratio (F=185.19, P<0.05). Also, Ochratoxin was found to have an increase the Melondialdehyde (MDA) in the treatment group relative of the control group (F=135.93, P<0.05). This study therefore clearly demonstrated a very strong link between Ochratoxin A and lipid peroxidation with this stated general objective of this study which is to investigate the role of Ochratoxin toxicity in lipid peroxidation and to investigate the effect Ochratoxin has on lipid peroxidation.

Keywords: Ochratoxin A, lipid peroxidation, Aspergillus, rat model, melondialdehyde.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • SEPTEMBER ISSUE PUBLISHED

    SEPTEMBER 2018 Issue has been successfully launched on 1 September 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT