Abstract
CYTOTOXIC ACTIVITY OF ANNONA MURICATA L. LEAF EXTRACT

*Sudha Karayil

ABSTRACT

Cancers are abnormal uncontrolled cell growth with the potential to invade or spread to other parts of the body. Conventional treatment of cancer includes chemotherapy, radiotherapy and surgery. All these treatments induce severe side effects. To reduce the side effects caused by these treatments, the use of alternative medicine which includes herbal drugs in the treatment of various diseases has expanded rapidly in both developed and developing countries. Herbal medicine is one of the most commonly used complementary and alternative therapies (CAM) by people with cancer. In the present work a plant selected for screening of anticancer properties which has been using long back for curing different ailments is Annona muricata belongs to the family Annonaceae. The leaves of the plant are tested for its cytotoxicity on L929 cell lines. The ethanol extract of leaf showed cytotoxic effect against L929 cells and further screening on different cell lines is in progress.

Keywords: Annona muricata, 2. Cell culture, 3. MTT assay, 4. Adjuvant.


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