Abstract
AGE-RELATED ALTERATIONS OF MITOCHONDRIAL FUNCTIONAL ACTIVITY OF RAT LIVER AND THE INFLUENCE OF HERBAL PREPARATIONS ON THEM

S.N. Dolimova, Sh.N. Kuziev*, G.M. Mukhamedzhanova and G.B. Umarova

ABSTRACT

It has been studied influence of herbal preparations “Megaferon” and MASGK on respiration processes and oxidative phosphorylation of liver mitochondria in rats of different ages and on the model of “accelerated aging”. It has been established that with the age of the animal it is observed uncoupling of the processes of respiration and phosphorylation of liver mitochondria, as well as inhibition of electron transfer in the respiratory chain. Similar data were obtained on the model of “accelerated aging” caused by irradiation of rats. Preparations created on the basis of natural compounds have a beneficial effect on the studied parameters and helped to restore the conjugation of mitochondria of “old” and irradiated rats.

Keywords: liver mitochondria, ROS, quercetin, rutin, energetic metabolism, oxidative phosphorylation, mtDNA damage.


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