Abstract
COMPARATIVE FORCED DEGRADATION STUDY OF THREE DIFFERENT BRANDS OF METFORMIN HCL (500MG) REGISTERED IN SUDAN

Mohamed Elamin Awadalla*, Dhia Eldin Abd Elmagied Elhag, Abutalib Alamin Abdallah, Alaa E. Elawni, Mohammed Abdeen and Hafiz Abdalrahman Mustafa

ABSTRACT

The aim of this study is to assess the stability of metformin HCl oral tablets (500 mg) upon subjecting to different acceleration stress conditions. This was achieved by determining the effect of temperature, UV light and humidity. Three brands registered in Sudan were subjected to the study, namely, Glucophage®, Formit® and Azaformin®. Glucophage® showed a sign of slight photo and thermal degradation and also showed a slight effect on the dissolution content after exposure to heat and humidity. The dissolution content of the three brands showed signs of slight effect by photolysis and also showed a decrease in potency.

Keywords: Forced degradation, photolysis, thermal degradation, stability, metformin.


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