Abstract
AMELIORATIVE POTENTIALS OF ADMINISTRATION OF VITAMIN C AND GARLIC FOLLOWING MERCURIC CHLORIDE INDUCTION IN THE KIDNEY MORPHOLOGY OF ALBINO WISTAR RATS

Gabriel D. Edem*, Ekemini I. Johnson

ABSTRACT

This study was aimed at assessing the perils of mercury (II) chloride poisoning in the morphology of the kidney of Albino Wistar rats and the ameliorating tendencies of administration of garlic and Vitamin C following mercury (II) chloride poisoning. 35 adult Albino rats of Wistar strain weighing 190-235g were used for this investigation. The animals were divided into 7 groups of 5 animals each. Group 1 rats received 5ml of distilled water, group 2 received 50.6mg/kg of HgCl2, group 3 received 50.6mg/kg of HgCl2 +90mg/kg of Vit C, group 4 received 50.6mg/kg of HgCl2 + 5ml of garlic solution, group 5 received 5ml of garlic solution, group 6 received 50.6mg/kg HgCl2 + 10 ml of garlic solution + 90mg/kg of Vit C and group 7 received 50.6mg/kg HgCl2 + 5ml of garlic solution + 90mg/kg of Vit C for 7 days. After the last dose schedule, the animals were sacrificed and the kidneys removed for histopathological examination. Results from this study reveals shrunken glomeruli, degeneration of Bowman capsule and increased periglomerular space in animals administered with 50.6mg/kg of HgCl2. Similarly, mild degeneration of Bowman capsule and normal glomeruli was evident in animals administered with 50.6mg/kg of HgCl2 +90mg/kg of Vit C. Sections of rats administered with 50.6mg/kg of HgCl2 +5ml of garlic solution showed mild shrunken glomeruli, mild increases in the periglomerular space and cytoplasmic vacuolation. Sections of rats administered with 5ml of garlic solution showed normal Bowman capsule, glomeruli and vacuolation. Sections of rats administered 50.6mg/kg of HgCl2 + 10ml of garlic solution + 90mg/kg of Vit C showed improved glomeruli architecture and improved Bowman capsule while sections of rats administered with 50.6mg/kg of HgCl2 + 5ml of garlic solution + 90mg/kg of Vit C showed mild improvement in glomeruli architecture and reduced enlargement of periglomerular space. It can therefore be concluded that mercury (II) chloride is poisonous to the kidney and that consumption of vitamin C and garlic may pose ameliorating impact on the morphology of the kidney.

Keywords: histopathological, periglomerular, Wistar, vacuolation.


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