Abstract
CORRELATION BETWEEN SEMINAL FLUID ANALYSIS AND LEVEL OF FSH, PROLACTIN AND TESTOSTERONE IN SUDANESE INFERTILE PATIENTS

Maha Mekki Abdellatef Omer*, Dr. Tarig Mohamed Fadl Elmula and Dr. Mohammed Rida

ABSTRACT

Background: Infertility, defined as the inability to conceive after at least one year of unprotected intercourse. The management of infertility problems has become an increasingly important part of health services during the past two decades in most countries. Recent studies have focused on semen quality of men in the general population. However, semen analysis and hormonal evaluation are prerequisite in the assessment of infertile men and level of hormones has direct effects on testicular functions and spermatogenesis. The general objective of this study is to correlate seminal fluid analysis and level of FSH, prolactin and testosterone in infertile Sudanese patients and specifically to measure the levels of these hormones and effect on parameters of seminal fluid analysis (SFA) and depicts if there is any correlation between level of serum FSH, prolactin and testosterone in healthy men and infertile patient. Methodology: One hundred semen samples, of Sudanese males attending reproductive health care centers, namely Ashmaig Center and AL Sirabuolhasan Center, were collected by masturbation after 3-5days prior abstinence from sexual intercourse. Of the total number, 80 infertile patients (age range:25-50years); classified into four categories, azoospermia, oligoazoospermia, asthenoazoospermia, and teratoazoospermia, and twenty apparently healthy subjects as controls (age range:27-40years). Levels of follicular stimulating hormone, prolactin, and testosterone were assessed, in addition to examination of seminal fluid analysis. Macroscopic and microscopic parameters of semen specimens were determined, as wet preparation for sperm motility, morphology and count. Results: The follicle stimulating hormone (FSH) level was markedly increased (p<0.05) in azoospermia and oligospermia, the testosterone level was found significantly decreased (p<0.05) in the infertile patients and decrease was clear in azoospermic patients. Prolactin level was significantly increased (p<0.05) in azoospermia and significantly increase in other infertile patients as well. Highly positive significant correlation was noticed between the FSH and sperm count in teratoazoospermia(p<0.005),and there is no significant correlation between the prolactin, follicular stimulating hormone, and testosterone with semen volume in infertile groups. Conclusion: In the infertile study groups testosterone level was decreased whereas FSH and prolactin levels were increased. This indicates an inverse relationship between testosterone level and the other reproductive hormones. The paper recommends that further study is needed to investigate the effect of Luteinizing hormone (LH) as it is produced by pituitary gland like FSH and may be linked to factors regulating spermatogensis.

Keywords: infertile males, semenquality, reproductive hormones.


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