Abstract
HYPOLIPIDEMIC POTENTIAL OF RAW SEEDS OF DACRYODES EDULIS ON WISTAR RATS

*Jessie Idongesit Ndem, Utibe Evans Bassey and Oboso Edem Etim

ABSTRACT

The phytochemical screening of ethanol extract of Dacryodes edulis seeds and its effect on lipid profile of albino Wistar rats was investigated. Fresh seeds were obtained, air-dried at room temperature and pulverized. The powder was macerated in 80% ethanol and the filtrate was concentrated to obtain crude extract. The crude extract was subjected to phytochemical screening and also administered to albino Wistar rats. Twenty-four (24) albino Wistar rats weighing between 150 – 180g were obtained and randomly selected into 4 groups with 6 animals in each group. Group I served as control while Groups II, III and IV served as test groups and were administered 100, 200 and 300 mg/kg body weight of the extract respectively, daily for 14 days by use of cannula attached to a syringe. All the animals were allowed access to rat feed and clean water ad libitum. Result show that the seed extract has a wide array of phytochemicals which include saponins, flavonoids, terpenes, alkaloids, tannins, cardiac glycosides and phlobatannins. Triglyceride, total cholesterol, LDL-cholesterol and VLDL-cholesterol concentrations were significantly reduced following the administration of the extract to Wistar rats while a dose dependent increase was observed in HDL-cholesterol concentrations. The ethanol extract of seeds of Dacryodes edulis is rich in phytochemicals and have a positive lipid modulatory effects.

Keywords: Decryodes edulis seeds, cholesterol, triglyceride, saponins, flavonoids.


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