Abstract
THE EFFECT OF OLANZAPINE TREATMENT ON SOME LIVER ENZYMES (AST, ALT & ALP) ON EXPERIMENTAL WISTER ALBINO RATS’ MODELS.

Alaa M. Shaomg*, Adil N. Morsi and Tarig M. Fadl-Elmula

ABSTRACT

Many of atypical antipsychotic drugs are associated with adverse metabolic effects, including obesity and obesity related liver diseases. Olanzapine is one of the atypical antipsychotic drugs used to treat schizophrenia, acute manic episodes and recurrence of bipolar disorders. This study aimed to evaluate the effect of olanzapine treatment on some liver enzymes (AST, ALT & ALP) On Wister Albino rats’ models. This study has been conducted at AlAhfad University, Omdurman, Khartoum state, Sudan from April to June 2016. A total of 24 Albino rats were divided into four groups: GroupІ served as untreated control group while the other three groups were divided corresponding to different human doses, GroupІІ olanzapine-treated with oral dose of 0.5mg\kg\day group, GroupІІІ olanzapine-treated with oral dose of 1mg\kg\day and GroupІV olanzapine-treated at a dose of 2mg\kg\day orally, six rats in each group. Baseline, intermediate and terminal serum ALT, AST and ALP were assessed in all four groups. The means of ALT & AST levels demonstrated notable increase in GroupІІІ and GroupІV when compared with control group after four weeks as well as their respective base line values from four weeks within their groups. At GroupІІ, the lowest olanzapine dose, there was a significant increase if ALT but no significant changes in AST level till the end of the experiment. There were no significant changes in the mean levels of ALP throughout the experiment in the four groups. Olanzapine induced liver ALT and AST in experimental Wister Albino rats at different human doses.

Keywords: Olanzapine, Atypical antipsychotic drug, NAFLD, NASH.


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