Abstract
EVALUATION OF C-REACTIVE PROTEIN FOR EARLY DETECTION OF KIDNEY IMPAIRMENT IN SUDANESE PATIENTS WITH HYPERTENSION AND TYPE 2DIABETES MELLITUS IN KHARTOUM STATE

Tasneem Ibraheem Ballah* and Tarig Mohamed Fadl Elmula

ABSTRACT

Background: C-reactive protein is a marker used for detection of chronic kidney disease in high risk patients (hypertensive and type 2 diabetes). Methodology: case-control study involving 75 subjects, age 40_80 years and different gender. Patients classified into diabetic patients with different duration and hypertensive patients also with different duration and control group. Renal function tests (urea and creatinine) and C-reactive protein were estimated. Results: A total of 75 patients included in the study, of whom 50% diabetes and hypertensive patients, diabetic male 5 (20%) and female 19(80%), hypertensive male 8 (32%) and female (68%), 25% apparently healthy subjects 14 (56%) Males and 11(44%) females. Glucose level and CRP were significantly increased in diabetic patients when compared to control group (p value = 0.00, 0.05) respectively. CRP was significantly increased in hypertensive patients compared to control group (p value=0.05). The correlation between duration of type 2 diabetes and hypertension and CRP levels was statistically significant compared to control group (p value = 0.04, 0.002) respectively. Conclusion: C-reactive protein was significantly increased in high risk population and correlate with diabetes and hypertension duration, it might serve as marker for early detection of chronic kidney diseases in such population.

Keywords: C-reactive protein (CRP), Chronic kidney diseases (CKD).


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