Abstract
ABNORMALLY RAISED CA125 IN A PATIENT OF LUMP IN ABDOMEN, DILEMMA IN DIAGNOSIS

Dr. Shrikant Dhumale*, Dr. Shalini Mahana Valecha and Dr. Binti Bhatiyani

ABSTRACT

A 42 years old woman presented with a lump in abdomen that caused abdominal protuberance also complained of menorrhagia and stress urinary incontinence. Ultrasonography revealed a 15x14x13 cm mass developed from her uterus. Her cancer antigen 125 (CA125) serum level at presentation was 4,321 U/mL and lactate dehydrogenase (LDH) level was 487 U/L. The suspicion was of a malignant neoplasm, so we undertook an exploratory laparotomy. Intraoperatively multiple uterine fibroids were noted, ovaries found to be normal. Frozen section sent, suggestive of leiomyoma. The pathologic diagnosis was a leiomyoma of the uterus. Both the Cancer Antigen125 and Lactate Dehydrogenase serum levels dropped unusually rapidly to normal after the operation. Usually with such high levels of Cancer Antigen 125 in association of abdominal mass suspicion of ovarian pathology is made but very rarely as in this case, uterine pathology may present with such abnormally raised levels of Cancer Antigen 125.

Keywords: CA125, Uterine leiomyoma, Lower abdominal lump.


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