Abstract
THE RELATIONSHIP BETWEEN CLINICALLY MANIFEST GASTRODUDENAL DISEASE AND THE GENOTYPE OF THE ASSOCIATED HELICOBACTER PYLORI ORGANISM

Eman Zaki Azzam*, Ezzat Ali Ahmed, Wafaa Mohammed Hussein Mekky, Shwikar Mahmoud Abd El-Salam, Essam El Din Abd El Gawad Abd El Khaliq

ABSTRACT

Infection with H. pylori has been associated with gastroduodenal diseases such as gastritis, gastric ulcer, duodenal ulcer, gastric cancer and mucosa- associated lymphoid tissue lymphoma (MALT lymphoma). The aim of this study was to detect the relationship between clinically manifest gastroduodenal disease and the genotype of the associated H. pylori organism. The study was conducted on 20 control subjects and 100 patients suffering from upper gastro-intestinal symptoms in the form of dyspepsia, epigastric pain, vomiting, heartburn, hematemesis and melena in which infection with H. pylori was detected by monoclonal antibody based H. pylori stool antigen test. Upper gastrointestinal tract (GIT) endoscopy was performed in all subjects as well as samples from gastric antral mucosa were obtained to detect H.pylori by rapid urease test, Polymerase chain reaction (PCR) for detection of H.pylori strain and the presence or absence of its virulence factors. Results showed that CagA and VacA are two virulence factors that can affect the clinical outcome of H.pylori and there was a significant positive association between the presence of CagA+ve strains and gastroduodenal diseases. VacA s1 genotype was associated significantly with gastroduodenal diseases but VacA m1 allele showed insignificant association.

Keywords: H.pylori, CagA, VacA, gastroduodenal diseases, PUD, gastric malignancies.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS NEW ISSUE PUBLISHED

    Its Our pleasure to inform you that, EJBPS October 2017 Issue has been Published, Kindly check it on http://www.ejbps.com/ejbps/current_issues

  • OCTOBER ISSUE PUBLISHED

    OCTOBER 2017 Issue has been successfully launched on 1 October 2017

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 45.77, due to High Quality Publication in EJBPS at International Level

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 3.881 to 4.382 due to high quality Publication at International Level.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT