Abstract
FORMULATION OPTIMIZATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF PIOGLTAZONE

Shaikh Siraj Nawaj*, Shaikh Zaker, G. J. Khan, Patel Zuber and Mujahid Khan

ABSTRACT

The objective of this study was to formulate and optimize Mucoadhesive buccal tablets of Pioglitazone using Carbopol as mucoadhesive polymers and evaluate results of the formulations. The Mucoadhesive buccal tablets of 200 mg were prepared by using polymers Carbopol 940 as primary and HPMC K100M as secondary polymer separately in various concentrations. Formulation batches were designed with the help of Design Expert software. Tablets were prepared by direct compression method, total nine batches were formulated. Drug excipient compatibility was determined by FTIR spectroscopy method and DSC. Results of FTIR and DSC revealed that there was no interaction between Pioglitzone and polymers. The tablets were evaluated for hardness, thickness, friability, weight variation, drug content, and surface pH, swelling index, In-vitro drug release, mucoadhesive strength and In-vitro residence time. Among 9 batches, FB5 and FB4 batches showed better results. The Ex-Vivo diffusion study of best release batches FB1, FB4 and FB5 were performed by using Goat Mucoadhesive buccal membrane on Franz diffusion Cell Apparatus. The best formulations batch FB5 showed Korsmeryer-Peppas order release with optimum release in buccal cavity.

Keywords: Mucoadhesive, Mucoadhesive buccal, bioadhesion, modified physical balance.


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