Abstract
SCREENING OF IMMUNOMODULATORY POTENTIAL OF HERBAL LEADS FROM SIDDHA FORMULATION POOVARASU NEI BY IN-SILICO DOCKING TECHNIQUE

R. Bharathi Sri*, C. Shanmugapriya and R. Meenakumari

ABSTRACT

Atopic dermatitis is a commonly occurring inflammatory skin disease in children’s which is characterized by itching, redness, swelling,crusting and scaling. Siddha system of traditional medicine has several formulations made of herbs with bioactive phytocomponents which is effective against atopic dermatitis. The key mediators actively involved in inflammatory condition like dermatitis are histamine, IL6, TNF-alpha, Cyclooxygenase I and II. Hence the main aim of the present investigation is to screen the anti-allergic and anti-inflammatory potential of phytocomponents such as Kaempferol, Mansonone, Thespone present in the formulation Poovarasu Nei (PN) against target protein Histamine 1 receptor with PDB code 3RZE, IL6 Interleukin with PDB code 1P9M, TNF alpha with PDB 2AZ5, Cyclooxygenase II with PDB 6COX and Cyclooxygenase I with PDB 3KK6 along with their respective standards using computational docking analysis. The results of the study indicates that the lead kaempferol, thespone and mansonone possess significant COX I, TNF alpha and IL 6 inhibition activity. Further the lead kaempferol and thespone also possess significant inhibition of COX II and H1 receptors, whereas the compounds mansonone has no activity against these proteins. Based on the results of the In-silico screening analysis it was concluded that the compound’s such as kaempferol, thespone and mansonone present in the siddha formulation PN possess significant inhibition of inflammatory mediators therefore this formulation may have promising immuno modulatory activity and may effective against atopic dermatitis.

Keywords: Atopic dermatitis, Siddha system, PoovarasuNei, Histamine, IL6, TNF-alpha, Cyclooxygenase, Immuno modulatory activity.


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