Abstract
FORMULATION AND EVALUATION OF ORALLY FAST DISSOLVING WAFER OF ETODOLAC USING NATURAL GUM

Darekar A. B., Sonawane S. M.* and Saudagar R. B.

ABSTRACT

Oral Wafers are intended for the application in the oral cavity on the tongue, drug absorbs totally through tongue artery and entered in to systemic circulation. So, they are an innovative and promising dosage form especially for use in pediatrics and geriatrics. Etodolac was selected as the active drug as it has low solubility and it is indicated in to Anti-arthritis where an immediate relief is always needed. The prepared wafers, based on different formulations, were evaluated. A 32 full factorial design was used to optimize the film. Natural Gum was found to be a good film forming agent. The concentration of PVP and Grevillea Robusta Gum were selected as independent while % drug release was a dependable variable in the formulation. Formulation F9 was found to be the optimized among all nine batches with 98.26% release. Increased in the levels of PVP K30 causes the decreased in the folding endurance and increased in the % elongation. Surface pH of all the formulation was measured and found in acceptable pH range. DSC spectra of film shown the drug was totally embedded within polymer matrix, so stability of drug was also increased in formulation. Stability study showed that formulation was stable over a period of stability conditions without any unacceptable changes.

Keywords: Etodolac, Solvent Casting, Oral Wafer, Grevillea Robusta Gum, PVP K30.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS NEW ISSUE PUBLISHED

    Its Our pleasure to inform you that, EJBPS October 2017 Issue has been Published, Kindly check it on http://www.ejbps.com/ejbps/current_issues

  • OCTOBER ISSUE PUBLISHED

    OCTOBER 2017 Issue has been successfully launched on 1 October 2017

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 45.77, due to High Quality Publication in EJBPS at International Level

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 3.881 to 4.382 due to high quality Publication at International Level.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT