Abstract
SYNTHESIS, CHARACTERIZATION, AND ANTIBACTERIAL EVALUATION OF NEW BENZIMIDAZOLE BEARING THIOESTER MOIETY

Muayed Ahmed Redayan*, Maha Salih Hussein and Ashraf Tark Lafta

ABSTRACT

The present work comprises synthesis of new derivatives for benzimidazole. The Compounds 1(a-d) were prepared by reaction of (4) un-substituted-o-phenylenediamine with carbon disulfite. Then compounds 1(a-d) used to prepare The thioester compounds 2(a-d) by reaction of compounds 1(a-d) with chloro acetyl chloride. The chemical structure of all synthesized compounds were confirmed by FT-IR and some by 1H, 13C-NMR. Some selected compounds were evaluated in vitro for their antibacterial activity against two types of Gram-positive bacteria namely (Staphylococco usaureus, Bacillus subtilis) and Gram-negative bacteria namely (Pseudomonas aeruginosa, Esherichia coli). Most of the results of the antibacterial activity of these compounds were good when comparison with the standard antibiotic ampicillin and ciprofloxacin.

Keywords: 2-Mercaptobenzimidazole, thioester, o-phenylenediamine.


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