Abstract
BLOOD BIOCHEMICAL AND HAEMATOLOGICAL ALTERATIONS IN SCHISTOSOMA MANSONI INFECTED PATIENTS IN IJORA – BADIA NIGERIA

Emmanuel Tonbra Egoro*, Godwin Ikhide Ilegbedion, Zebedee Udu Loveday and Mosun Shakirat Shonibare

ABSTRACT

Schistosomiasis is an infection of significant health concern. The aim of this study was to assess the alterations of some blood biochemical and haematological parameters in Schistosoma mansoni infected patients. Blood specimens were collected from 35 patients infected with 2+ ova of Schistosoma mansoni (experimental group) and another 35 subjects with no evidence of Schistosoma mansoni infection (control group) into lithium heparinized and ethylene diamine tetraacetic acid (EDTA) anticoagulated bottles respectively. The following biochemical and haematological parameters were measured using the specified methods: alanine aminotransferase (colorimetric), aspartate aminotransferase (colorimetric), alkaline phosphatase (colorimetric endpoint), total bilirubin (Jendrassik and Grof), total protein (biuret), albumin (bromocresol green), C-reactive protein (latex turbidimetry), haemoglobin (cyanmethaemoglobin), erythrocyte sedimentation rate (westergren) and total white blood cell count (improved neubauer chamber). The results showed that the mean values of plasma alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, total protein, albumin, C-reactive protein, blood haemoglobin, erythrocyte sedimentation rate and total white blood cell count were statistically significant (p≤0.05) in the experimental group as compared with the mean values of the control group. However, the mean values of plasma cholesterol and uric acid were not statistically significant (p≥0.05) in the experimental group as compared with that of the control group. The percentage of subjects in the experimental group having plasma alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, cholesterol, uric acid, C-reactive protein, erythrocyte sedimentation rate and total white blood cell concentrations above the existing reference ranges maximum of 12.0U/I, 12.0U/I, 35.0 IU/L, 17.0 μmol/L, 5.17 mmol/L, 416μmol/L, 6.0mg/L, 7.0mm and 11.0×103cmm were 80%, 74%, 57%, 57%, 20%, 17%, 66%, 60% and 57% respectively while the percentage of subjects in the experimental group with concentrations lesser than the existing reference ranges minimum of 64g/l (total protein), 38g/l (albumin) and 12g/dl (haemoglobin) were 74%, 74% and 60% respectively. In conclusion this study has shown that the above mentioned blood biochemical and haematological parameters with statistical significant mean values are altered in chronic Schistosoma mansoni infection.

Keywords: Schistosoma mansoni infection, blood biochemical alterations, blood haematological alterations, Ijora-Badia, Nigeria.


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