Abstract
EVALUATION OF KYNURENIC ACID ATTENUATES ETHANOL WITHDRAWAL INDUCED HYPEREXCITABILITY IN MICE

K.V. Ambulkar, P.C. Patle, D. T. Gautam*, C. R. Tenpe, S. S. Rathod, V. S. Mule, A. M. Patole, V. A. Jagtap

ABSTRACT

The present study was undertaken to investigate the effects of kynurenic acid attenuates hyperexcitability after ethanol withdrawal in mice. Acute and chronic administration of both kynurenic acid and diazepam (or saline) which mice exhibited peak ethanol withdrawal-induced hyper excitability. Treatment with kynurenic acid (50 or 100 mg/kg, i.p.), 30 min prior to peak ethanol withdrawal-induced hyper excitability signs (7 h), significantly reduced ethanol withdrawal-induced hyper excitability sign scores compared with the vehicle treated group, whereas a lower dose (50 mg/kg, i.p.) did not influence the ethanol withdrawal-induced signs. In other experiments, administration of diazepam (1.25 or 2.5 mg/kg, i.p.), 30 min prior to peak (7 h), dose-dependently attenuated the withdrawal signs, whereas a lower dose (0.625 mg/kg, i.p.) did not influence the ethanol withdrawal-induced signs. Acute treatment with kynurenic acid and diazepam in the control liquid-diet groups had no influence on the physical signs of hyper excitability. In line with the above, it was observed that acute effect of kynurenic acid did not show any significant effect on locomotor. The significant effects on locomotor activity compared with the Vehicle treated animals. In contrast, diazepam (2.5 mg/kg, i.p.) significantly reduced chronic treatment with kynurenic acid exhibited prevention in hyper locomotor effect of ethanol withdrawal. The results and evidence suggest that kynurenic acid exhibited an inhibitory influence against ethanol withdrawal-induced hyper excitability signs which could be mediated through its neuromodulatory & neuroprotective action.

Keywords: Kynurenic acid, Hyperexcitability, Ethanol Withdrawal, NMDA Receptor.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS NEW ISSUE PUBLISHED

    Its Our pleasure to inform you that, EJBPS November 2017 Issue has been Published, Kindly check it on http://www.ejbps.com/ejbps/current_issues

  • NOVEMBER ISSUE PUBLISHED

    NOVEMBER 2017 Issue has been successfully launched on 1 November 2017

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 45.77, due to High Quality Publication in EJBPS at International Level

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 3.881 to 4.382 due to high quality Publication at International Level.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT