Abstract
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF ISONIAZID DRUG BASED TRANSITION METAL COMPLEXES

K. K. Mothilal*, S. Radha and A. Thamaraichelvan

ABSTRACT

A series of five transition metal complexes of the type, [M(INH)2(H2O)(NO3)] (NO3), where M = Mn(II) (1), Co(II) (2), Ni(II) (3), Cu(II) (4), Zn(II) (5) and INH =isoniazid, have been synthesized with the drug, isoniazid (INH) Nitrate ion and water as ligands. The complexes were characterized by elemental analyses, conductance measurements, electronic, infra red, electron spin resonance and thermal studies. All complexes adopt octahedral geometry around the metal ion. The redox properties of the complexes were investigated by cyclic voltammetry (CV). All the complexes, exhibited quasi-reversible single/two electron transfer behavior. The ligand and its metal complexes have been screened for in vitro antibacterial and antifungal properties. These results revealed that all complexes showed significant activity. DNA binding and cleavage studies showed that all metal complexes have significant activities than the Isoniazid ligand.

Keywords: Isoniazid complexes, Redox behavior, Thermal studies, Antimicrobial activity, Cyclic voltammetry.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS NEW ISSUE PUBLISHED

    Its Our pleasure to inform you that, EJBPS November 2017 Issue has been Published, Kindly check it on http://www.ejbps.com/ejbps/current_issues

  • NOVEMBER ISSUE PUBLISHED

    NOVEMBER 2017 Issue has been successfully launched on 1 November 2017

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 45.77, due to High Quality Publication in EJBPS at International Level

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 3.881 to 4.382 due to high quality Publication at International Level.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT