Abstract
EFFECTS OF DIGESTI’VAS, APOLYHERBAL FORMULATION ON GASTROINTESTINAL- RELATED MEASUREMENTS IN RODENT MODELS

Ume Nishar Banu S., Abhishek Mondal, Abhishek K., Samhitha J., Shivalinge Gowda K. P.*, Shanaz Tejani- Butt, Nataraj Loganayaki, Khader Shareef K. S. and Venkateswarlu K.

ABSTRACT

Aim: The present study evaluated the activity of Digesti’Vas on gastrointestinal motility, appetite and hepatoprotective effects in a rodent model. Methods: Digesti’Vas is a polyherbal formulation developed by Suguna Foods Pvt Ltd. Acute toxicity and gastrointestinal motility activity were evaluated in mice. Appetite activity and potential hepatoprotective effects were evaluated in rats. Results: Since Digesti’ Vas did not exhibit acute toxicity when given orally up toa concentration of 2000 mg/kg bw, 200mg/kg body wt(1/10th of 2000 mg/kg) was selected as the median dose. Digesti’Vas showed a significant increase in mean defecation period (346.2 ± 65.83min), comparable to the positive control, loperamide (383.0 ± 37.83min), in comparison to the normal control group (251.2 ± 60.32min). Digesti’Vas treatment also led to a significant increase in the percentage change in body weight (8.367±3.021 g) when compared to the normal control group (3.618±2.088g) and a significant increase in percentage change in food intake (13.28±3.673 g) when compared to the normal control group (8.657±2.160 g). When measurements were done on various liver parameters, it was found that Digesti’Vas treated animals showed a significant decrease in serum ALP levels (401.8±10.04U/L) compared to CCl4 treated animals (493.2±108.4 U/L); comparable to the positive control, Silymarin (370.5±37.82 U/L). Digesti’Vas significantly decreased serum SGPT levels (57.03±66.01U/L), compared to CCl4 treated animals (420.8±214.1 U/L); in agreement with levels seen in Silymarin treated animals (61.39±37.87 U/L).Furthermore, Digesti’Vas significantly decreased SGOT (6.953±3.712 U/L) levels compared to the CCl4 treated group (29.65±5.765 U/L), in keeping with levels seen after treatment with Silymarin (10.71±6.135 U/L). Conclusion: This study suggests that Digesti’Vas, a herbal preparation that is formulated by Suguna Foods Pvt Ltd, possesses antimotility, hepatoprotective, and increased appetite effects in a rodent model. Future studies investing the role of Digesti’Vas in alleviating gastrointestinal disorders are certainly warranted.

Keywords: Appetite, Digesti’Vas, Gastrointestinal motility, Loperamide, SGOT (Serum Glutamic-Oxaloacetic Transaminase).


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