Abstract
PROTECTIVE ROLE OF SOLANUM NIGRUM LINN LEAF METHANOL EXTRACT ON MALE WISTAR ALBINO RATS AGAINST N-NITROSODIETHYL AMINE INDUCED HEPATOCARCINOMA

Pandurangan Ayyanar, Rajenderan Murugan and Natesan Manoharan*

ABSTRACT

The protective role of Solanum nigrum Linn. was studied in N-nitrosodiethyl amine induced hepatocarcinoma on Wistar albino male rats. The haematological content RBC count, WBC count, Platelet count, PCV, Hemoglobin and ESR were studied and results showed significant (P≤0.001) increased production was recorded. In addition to that liver markers enzyme serum glutamate pyruvate transaminase, serum glutamate oxaloacetic transaminase, acid phophatase, alkaline phophatase, lactate dehydrogenase and γ-glutamyl transpeptidse, and serum biochemical parameters, bilirubin, creatinine, urea, uric acid and serum protein were analyzed. The lipid peroxidation (LPO) and lipid profile were also estimated along with histopathological study in liver tissue. All the parameters are statistically calculated at P≤0.001, P≤0.01and P≤0.05. The recorded results showed significant revert changes in experimental liver tissue.

Keywords: Hepatocarcinoma, Solanum nigrum, N-nitrosodiethyl amine.


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