Abstract
FORMULATION CHARACTERIZATION AND EVALUATION OF TRANSDERMAL PATCHES OF GLIMEPIRIDE

Pabbiniddi Veera Lakshmi* and Chepuri Prasanthi

ABSTRACT

Transdermal drug delivery systems (TDDS), are the dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. The aim of the present study was to formulate, characterize and evaluate transdermal patches of glimepiride by solvent casting method employing natural polymers like sodium alginate and xanthan gum. The prepared formulations were evaluated for different physicochemical characteristics like Weight Variation, Folding Endurance, thickness uniformity, %Moisture uptake, %Drug Content & %Drug Release. The drug release characteristics of the formulation were studied in-vitro by using Franz diffusion cell. The in-vitro drug release plot showed that the drug release followed zero order kinetics & Higuchi model, which was evidenced from the regression values. Based on the drug release and physicochemical values, formulation EF4 was considered as an optimized formulation which shows higher percentage of drug release (70.13±0.26% at 24 hour) with diffusion mediated mechanism. Korsmeyer-Peppas exponential plots shows fairly linear and it is well supported by their regression coefficient values & slope values (n) which suggest that drug was released by Super Case-II transport.

Keywords: Glimepiride, Transdermal drug delivery systems, Solvent casting method.


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