Abstract
THE ROLE OF ALDH2 AND ADH1B POLYMORPHISM IN ALCOHOL DEPENDENCE: A CASE- CONTROL STUDY FROM BILASPUR, CHHATTISGARH, INDIA

Arjun Rao*, Akhilesh Tiwari, Moumita Sinha, Sujit Nayak, Sudhanshu Bhatt and Bharti Ahirwar

ABSTRACT

Polymorphism at the functional region of the gene encoding Alcohol Dehydrogenase (ADH) 1B and Aldehyde Dehydrogenase (ALDH2) are viewed as most essential among a few hereditary factors causing complex disorder - Alcohol Dependence. From population of India, there is insufficient account of data on commonly studied Arg47His and Glu487Lys polymorphisms from Alcohol Dependent subjects. In this article, we report for the first time, allelic and genotypic frequencies of Arg47His and Glu487Lys single nucleotide polymorphisms (SNPs) in Chhattisgarh population (Central India). A sum of 50 Alcohol Dependent Cases, satisfying DSM IV criteria and 50 age sex matched controls were genotyped utilizing the Polymerase Chain Reaction– Restriction Fragment Length Polymorphism technique. The feature of the examination findings was the interestingly high frequency of the ALDH2*2/*2 genotype (among Alcohol Dependent Cases) being a risk genotype for Alcohol Dependence.

Keywords: Alcohol dependence, alcohol dehydrogenase, aldehyde dehydrogenase, genotype, allele frequency.


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