Abstract
METHYL ACETATE FRACTION OF METHANOLIC EXTRACT OF SCHREBERA SWIETENIOIDES ROXC. ROOT FOR IT’S ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES

Syed Wajid and *Taqui Mohammed

ABSTRACT

Ethanolic extract of Schrebera swietenioides roxb. (SSE) root was prepared by soxhlation method and screened for its in vitro antioxidant, anti-inflammatory (acute, chronic) and antipyretic activity in wistar rats. Antioxidant assay was performed by using DPPH, ABTS and Lipid peroxidation assay methods. In antioxidant assay, % inhibition and IC50 was calculated. SSE produced 50% inhibition (IC50) at 1.7 μg in DPPH, 4.35μg in ABTS, 23.53μg in lipid peroxidation assay and shown more potent antioxidant activity compare to standard compound. Anti-inflammatory activity was performed by using carrageenan induced paw edema and complete Freund’s adjuvant arthritis in rats. In these assays, SSE showed dose dependant inhibition in paw edema. Maximum inhibition was found at 300 mg /kg oral dose of SSE in rats. In Carrageenan induced paw edema SSE showed maximum 67.81% inhibition and in freund’s adjuvant arthritis it showed maximum 50% inhibition at 300 mg/kg oral dose in rats, which was significantly different from control (p<0.05). SSE also showed dose dependant decrease in body temperature in brewer’s yeast induced pyrexia in rats. SSE significantly decrease in body temperature (p<0.05) at 300 mg/kg compare to control. Present study showed that SSE had significant antioxidant, anti-inflammatory and antipyretic activity.

Keywords: Antioxidant, anti-inflammatory, antipyretic, Schrebera swietenioides roxb., DPPH, ABTS.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • EJBPS NEW ISSUE PUBLISHED

    Its Our pleasure to inform you that, EJBPS December 2017 Issue has been Published, Kindly check it on http://www.ejbps.com/ejbps/current_issues

  • DECEMBER ISSUE PUBLISHED

    DECEMBER 2017 Issue has been successfully launched on 1 December 2017

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 3.881 to 4.382 due to high quality Publication at International Level.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT