Abstract
EVALUATION OF PLASMA HOMOCYSTEINE LEVEL IN DIABETES MELLITUS PATIENTS IN KHARTOUM STATE

*Rowaida Mamoon Mukhtar and Ibrahim Khider Ibrahim

ABSTRACT

Background: Diabetes mellitus (DM) Is metabolic disorder characterized by chronic hyper glycemia with disturbance in carbohydrate, fat and protein metabolism arising from defect in insulin secretion, action or both.[1] The pathophysiology of DM characterized by high incidence of vascular complications, in recent years it had be reported to be associated with the vascular complications of diabetes. Elevated Hcy levels were associated with insulin resistance and nephropathy, also predict the risk of coronary events. Objectives: The aim of this study to measure homocysteine level in diabetes mellitus patients using ELISA and to correlate the homocystiene level with patient, s, age, gender and type of diabetes. Material and Methods: cross sectional study was performed In Al-Mogran University Hospital, Khartoum, Sudan. A total of 30 Sudanese diabetic patient were included in this study, 15 (50%) were males and 15 (50%) were females, their age ranged between 12to 80 years. Homocystiene level were measured using immune assay ELISA. Data were analyzed by using statistical package for the social science (SPSS) computerized program version 11.5. Results: The present study showed that the mean of plasma homocysteine level is(15.010) which was slightly increase according to normal range (5-14 ╬╝mol/L), also the results showed that was significantly higher compared to normal range(P-value 0.00). Conclusion: there was slightly increased in plasma homocysteine level in diabetic patients.

Keywords: Diabetes mellitus (DM) homocysteine level in diabetic patients.


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