Abstract
ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE T-786C POLYMORPHISM AMONG PREGNANT SUDANESE WOMAN IN KHARTOUM 2017

Ebtihal Ahmed Mohammed*, Nafisa Galal Hassan, Eman Awad Wedaa and Sara Mudawi Abdalmajeed

ABSTRACT

A single nucleotide polymorphism (T > C) rs2070744 due to transition of a thymine to a cytosine at T-786C in the promoter region of eNOS was found to reduce the rate of mRNA transcription by 50%, resulting in decreased serum NO levels which can inhibit apoptosis or stimulate tumor proliferation, angiogenesis and metastasis. To evaluate the association between Nitric Oxide Synthase Gene T-786C polymorphism and pregnant woman in Sudan. A total of 40 patients pregnant woman and 50 control subjects were enrolled this study. DAN extrication samples were extracted from EDTA Blood using guanidine chloride method. Analysis of the eNOS786T > C promoter polymorphism were carried out by allele specific polymerase chain reaction method (PCR). The present study reported that, molecular analysis showed that, the most frequent genotype in patients was TT 95% (38) followed by TC genotype 5% (2). While in the control group there was 100% TT genotype. The present study indicates the lack of association between eNOS and pregnant woman which needs to be investigated in a study with larger samples.

Keywords: Polymorphism, Investigated, Polymorphism and Pregnant.


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