Abstract
SEROPREVALENCE OF ANTI-CARDIOLIPIN ANTIBODIES IN SUDANESE PATIENTS WITH RENAL FAILURE IN KHARTOUM STATE, SUDAN

Nusaiba Ali Hamza and Mahdi H. A. Abdalla*

ABSTRACT

Background: Antiphospholipid antibodies are a heterogeneous circulating immunoglobulins family of approximately twenty auto antibodies directed against phospholipids binding plasma proteins. Anticardiolipin (ACL) is the most commonly investigated APL in relation with several diseases as Rheumatoid arthritis, systemic thrombosis, cerebral ischemia, deep vein thrombosis and renal failure . Anti-cardiolipin antibodies can be classified in two ways; As IgM, IgG or IgA and as ß2-glycoprotein dependent or independent. Renal failure (RF) is a condition in which the kidneys fail to remove metabolic end-products from the blood and regulate the fluid, electrolyte, and pH balance of the extracellular fluids. Objective: This study aimed to investigate the Seroprevlance of ACL among renal failure patients. Materials and Methods: this is a case-control study conducted in an Integrated Mdedical Lab and Al-Ryadah Medical Laboratories in Khartoum, Sudan from March to May 2017. It included one hundred samples; 50 cases and 50 controls, IgG and IgM anti-cardiolipin were investigated using ELISA. WBCs, PLT, Hb, HCT and RBCs were determined by automated cell analyzer. Results TWBCs were significantly higher in renal failure patients than control (P=0.000). Platelets didn’t show significant difference between case and control(P=0.754). IgAGM anticardiolipin antibodies positive results were found in 14 (14.1%) in 100 participants.Positive results were 85 (85.9%), out of 14 (14.1) positive results 10 (71.4) were positive in the case groups while 4 (28.6%) were positive in control group, negative result was 40 (47.1%) in case and 45 (52.9%) in control group. There is no significant different between case and control with P.Value 0.080. Conclusion: IgAGM anticardiolipin antibodies were positive in 10 cases and 4 controls with no significant different between case and control.

Keywords: Anti-Cardiolipin Antibodies, Renal failure, Sudan


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