Abstract
ACTIVITY OF DIZOCILIPINE AND ITS COMBINATIONS WITH DANTROLENE AND LISURIDE ON THE LD50 PERIOD IN MICE WITH EXPERIMENTAL TETANUS

Indira Mujezinovic, Muhamed Katica*, Ahmed Smajlovic, Nedzad Gradascevic

ABSTRACT

Tetanus intoxication is a result of combined tetanus toxin binding in the organism: centrally in the spinal cord at the level of inhibitory synapses and peripherally at the level of the neuromuscular junction and muscle cell. Although acute intoxication is dominated by the central action of tetanus toxin, it is considered that, for the purpose of successful implementation of therapy, peripheral activity of the tetanus toxin should be also antagonized. Experimental tetanus was induced by intramuscular application of tetanus toxin. Application of substances on mice in experimental groups was performed after the occurrence of local tetanus in right leg, approximately 24 hours after administration of tetanus toxin. In this research, we attempted to normalize disorders caused by tetanus toxin using dizocilipine maleate (at doses of 0.01; 0.1; 1.0 and 2.0 mg/kg b.w.), alone and in combination with dantrolene (at dose of 2.0 mg/kg) and lisuride (at dose of 50.0 μg/kg) on the LD50 period in mice with experimental tetanus in the trial. Through our research, we found that dizocilipine had the best effect at a dose of 0.1 mg/kg b.w. Additionally, combination of dizocilipine and lizuride had no effect on the LD50 period, as compared to the control group.

Keywords: Tetanus, Tetanus Toxin, Dizocilipine, Dantrolene, Lisuride.


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