Abstract
FORMULATION AND CHARACTERIZATION OF FAROPENEM SODIUM EMULGEL FOR TOPICAL APPLICATION

*Kavita Varma and Dr. Seema Kohli

ABSTRACT

Topical drug delivery systems have been utilized for centuries for the treatment of local skin disorders. One side the topical applications of the drug provides the potential advantages of delivering drug straightly to the site of action and delivering drug for extended period of time at the effected site that mainly acts at the related regions. On the other hand, topical delivery system elevates the contact time and mean resident time of drug. The objective of the study was to prepare emulgel of Faropenem sodium, using Carbopol 940 and 934 as a gelling agent. Propylene glycol was used as penetration enhancer. The emulsion was prepared and it was incorporated in gel base. The formulations were evaluated for rheological studies, spreading coefficient studies, extrusion studies, skin irritation studies, in vitro release, ex vivo release studies. Stability studies showed satisfactory results. It can be concluded that faropenem sodium emulgel showed good consistency, homogeneity, spreadability and stability and has wider prospect for topical preparations.

Keywords: Emulgel, Faropenem Sodium, Topical gel, Carbopol.


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