Abstract
FORMULATION AND IN VITRO EVALUATION OF EFFERVESCENT FLOATING TABLETS OF MEBENDAZOLE

Sandhya Adimulka*, Adukondalu Devandla, M. Ravi and B. Kasturi Bai

ABSTRACT

In the present research work the gastro retentive floating matrix formulation of Mebendazole by using various hydrophilic polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various natural polymers. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations prepared by using Sodium CMC were unable to produce desired drug release, they were unable to retard drug release up to 12 hours. The formulations prepared with Chitosan retarded the drug release up to 12 hours in the concentration of 200 mg (F6).The formulations prepared with Guar gum were also retarded the drug release for more than 12 hours. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed Higuchi mechanism of drug release.

Keywords: Mebendazole, Guar gum, Sodium CMC, Chitosan, Floating tablets.


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