Abstract
ANTIPYRETIC ACTIVITY OF VARIOUS KARIYAT EXTRACTS IN EXPERIMENTAL ANIMALS

Kalavati Jambigi*, Preeti V. K., A. R. Kulkarani and Aditya Parashar

ABSTRACT

The present study was undertaken to evaluate antipyretic activity of various kariyat extract in various experimental animals models. Antipyretic activity was carried out using Brewer’s yeast inducing pyresia in rats. Acute toxicity study was conducted for the extract and the test drug doses for screening were selected depending upon LD50 values Aqueous and ethanolic extracts of kariyat in the dose of 200 & 400 mg/kg body weight per oral were used. Aspirin was used as standard for antipyretic activity. Aqueous (KAE) and ethanolic (KEA) extract at higher dose (400 mg/kg) showed significant (P<0.01) decrease in elevated body temperature when compared with the control group. The maximum percentage reduction of 81.25% was observed for aspirin whereas for KEE and KAE was 68.25 and 81.87% respectively after 3 hr.

Keywords: Kiriyat, antipyretic, Brewer’s yeast induced pyresia.


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