Abstract
THE TIME AND DOSE DEPENDENT EFFECTS OF HALOFANTRINE HYDROCHLORIDE ON THE BIOCHEMICAL LIVER INDICES OF GUINEA PIG

Batubo Nimisoere P.*

ABSTRACT

Halofantrine hydrochloride is an antimalarial drug, usually prescribed as a standby treatment of malaria in travellers and pregnant mothers. In this study the time and dose dependent effects of halofantrine hydrochloride on liver biochemical indices during 24 hours treatment period of malaria. 48 female guinea pigs were used in this study and were equally divided into 3 groups of 16 each. The treatment group B and C received 2.6mg and 1.3mg of halofantrine hydrochloride as clinical and subclinical doses respectively at 6 hours interval for 3 doses while group A the control received distilled water alone. Signs of toxicity were observed throughout the study. No death was recorded in any of the treatment groups and also the guinea pigs did not show any abnormalities in their physiological characteristics. The liver biochemical indices such aspartate aminotransferase, alanine aminotransferase, total protein and albumin were significantly elevated at p<0.05 however there was a significant reduction alkaline phosphatase enzyme at p<0.05. It was also observed that the effects of halofantrine on the liver enzymes follow a biphasic activity. Based on this result, it can be concluded that halofantrine hydrochloride has a biphasic activity on liver enzymes and hepatotoxic in clinical and subclinical doses during treatment period. It is therefore contraindicated in patient with livers diseases or those at risk of liver disease.

Keywords: Halofantrine hydrochloride, biochemical indices, guinea pig, short-term treatment period.


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