Abstract
DEVELOPMENT AND EVALUATION OF OPHTHALMIC SUSPENSION CONTAINING CORTICOSTEROID AND ANTIBIOTIC

Deepak Kumar Sarangi*, Debashish Ghose, Suman Kumar Mekap, Rabinarayan Rana and Kanhu Charan Panigrahi

ABSTRACT

In the present study an attempt was made to develop and evaluate the ophthalmic suspension containing corticosteroid drug i.e Prednisolone and Quinolone antibiotic i.e Moxifloxacin. The pH of all formulations was found to be satisfactory in the range of 6.0-6.2, thus there would be no irritation to the patient upon administration of the formulation. The particle size analysis revealed that the particles were in nanometer range and all the formulations showed ideal surface morphology except F2 because after autoclave the particle size of formulation was increased and found to be 17.565 μm which was out of acceptable range. F1 was showed smallest particle size and discrete. The in vitro release studies indicated that the formulation F9 showed better effect for desired time and it was found that 120 minutes and 90 minutes for Prednisolone and Moxifloxacin respectively. From the stability studies as per ICH guidelines, it was confirmed that formulations of corticosteroid and antibiotic ophthalmic suspension remained more stable at ambient temperature (25°C) and relative humidity (40%) as compare to other stability conditions.

Keywords: Corticosteroids, Antibiotics, ICH, Surface morphology.


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