Sandhyarani Guggilla*, Kiran Gangarapu, Ammavenu and Sarangapanim


Taxane-based chemotherapy regimens constitute one of the most widely used cytotoxic antineoplastic treatments for various cancers including breast, gynecologic, lung, and genitourinary malignancies. taxanes have a wellknown toxicity profile that includes bone marrow suppression, hypersensitivity reactions, skin toxicities, doselimiting peripheral sensory neuropathy, and alopecia.[1] the taxane-induced myalgia–arthralgia syndrome (m-as) is a less well-understood toxicity, and it is distinct from taxane-associated peripheral neuropathy. m-as presents most often with moderate or severe generalized musculoskeletal pain the first hours or days after taxane administration. although in our clinical experience, severe pain after taxane administration is commonly encountered as a factor leading to patients’ requests for discontinuation of treatment, no data exist on the incidence of this occurrence that could decrease the overall efficacy of oncologic treatment. There is no consensus with regard to the treatment of this adverse effect. Various pharmacologic agents have been anecdotally reported as useful in treating the syndrome, but no randomized data exist.[2,3] We performed a retrospective review of the records in our clinic to identify patients treated with docetaxel for localized breast cancer who experienced taxane-induced M-AS so as to investigate possible risk factors for developing the syndrome and the effect that the syndrome has in delivering the scheduled dose of docetaxel, and to evaluate drug treatments.

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