Abstract
BREAST CANCER PATIENTS WITH MYALGIA–ARTHRALGIA SYNDROME

Sandhyarani Guggilla*, Kiran Gangarapu, Ammavenu and Sarangapanim

ABSTRACT

Taxane-based chemotherapy regimens constitute one of the most widely used cytotoxic antineoplastic treatments for various cancers including breast, gynecologic, lung, and genitourinary malignancies. taxanes have a wellknown toxicity profile that includes bone marrow suppression, hypersensitivity reactions, skin toxicities, doselimiting peripheral sensory neuropathy, and alopecia.[1] the taxane-induced myalgia–arthralgia syndrome (m-as) is a less well-understood toxicity, and it is distinct from taxane-associated peripheral neuropathy. m-as presents most often with moderate or severe generalized musculoskeletal pain the first hours or days after taxane administration. although in our clinical experience, severe pain after taxane administration is commonly encountered as a factor leading to patients’ requests for discontinuation of treatment, no data exist on the incidence of this occurrence that could decrease the overall efficacy of oncologic treatment. There is no consensus with regard to the treatment of this adverse effect. Various pharmacologic agents have been anecdotally reported as useful in treating the syndrome, but no randomized data exist.[2,3] We performed a retrospective review of the records in our clinic to identify patients treated with docetaxel for localized breast cancer who experienced taxane-induced M-AS so as to investigate possible risk factors for developing the syndrome and the effect that the syndrome has in delivering the scheduled dose of docetaxel, and to evaluate drug treatments.

Keywords: .


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • MAY ISSUE PUBLISHED

    MAY 2018 Issue has been successfully launched on 1 May 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT