Abstract
COMPARISON OF MEAN PLATELET VOLUME IN PATIENTS OF TYPE I DIABETES MELLITUS AND TYPE II DIABETES MELLITUS- A HOSPITAL BASED STUDY

S. Tahseen Raza, Seema Singh*, Nitin R. Gupta, Arvind Kumar, Alok Singh, Pooja Singh

ABSTRACT

Background: Diabetes mellitus (DM) is a global complex and pandemic disease. Its characteristics are metabolic abnormalities, hyperglycaemia and long term micro–macrovascular abnormalities along with blood vessels, eyes, nerves and kidneys. Platelets act as key factor in development of its thrombogenic complications. Recent studies reported about the platelet parameter such as mean platelet volume (MPV) in diabetic patients, contributing to increased risk of vascular disease. This study was carried out to compare the mean platelet volume in type I and type II diabetes mellitus patients and also compare MPV in males and females in type I and type II DM. Objectives: This study was conducted to compare the MPV in type I and II DM to predict it as simple and cost effective tool in this disease. Methods: This is a cross sectional hospital based study conducted in Integral Institute of Medical Sciences, Lucknow. Total 93 patients were included, in which 23 DM I and 70 DM II patients were included. MPV was measured by a 3 part differential hematology auto analyzer and data analyzed by ‘t’ test. Result: Mean MPV was significantly higher in the DM II patients in comparison to type I DM (9.95 ± 1.50 fl versus 9.17±1.69 fl.; p=0.039) In female patients, in type I DM patients the mean platelet volume was found to be 9.34±0.73.The mean platelet volume was found to be 10.07±1.38. The total mean platelet volume was found to be 9.96±1.32. In male patients, in type I diabetes mellitus patients, the mean platelet volume was found to be 9.12±1.89. The mean platelet volume in type II DM patients was found to be 9.86±1.59. The total mean platelet volume was found to be 9.64±1.71. Conclusion: High MPV in DM II in comparison to type I DM along with higher MPV in males and females in type II DM rather than type I DM. Thus MPV play as cost effective test for monitoring the patients with chronic Diabetes mellitus disorder.

Keywords: Diabetes Mellitus; Platelets; Mean platelet volume.


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