Abstract
ANTIHYPERTRIGLYCERIDEMIC PROPERTIES OF SORGHUM VULGARE LEAF SHEATH ON HAEMATOLOGICAL INDICES AND LIVER FUNCTION MARKERS ON HIGH FAT DIET DYSLIPIDEMIC WISTAR-ALBINO RATS

Akuru Udiomine B.* and Okoko Tebekeme

ABSTRACT

Hypertriglyceridemia is a condition in which the concentration of triglyceride in the blood is high. Hypertriglyceridemia can lead to atherosclerosis and severe conditions, acute pancreatitis. The aim of this study was to investigate the antihypertriglyceridemic properties of Sorghum vulgare leaf sheath on haematological indices and liver function markers on high fat diet dyslipidemic wistar-albino rats. Thirty-six Wistar-albino rats weighing 110-130g were used for the study. The animals were distributed randomly into six groups of six animals each. Group 1 (control), group II to group VI were induced with high fat diet; group II(untreated), groups III was treated with atorvastatin (0.2mg/kg), whereas groups IV to VI received 400mg/kg, 800mg/kg and 1200mg/kg of the plant extract respectively. The results of the study showed that aqueous extract of Sorghum vulgare leaf sheath (at 800mg/kg) significantly reduced (p≤0.05) triglyceride, Very low density lipoproteins and bilirubin concentrations. Aspartate aminotransferase activity and Alanine aminotransferase activities also reduced significantly(p≤0.05). Total cholesterol, Low Density Lipoprotein, High density lipoprotein, Red blood cell, Haemoglobin, Packed cell volume, Neutrophils and Lymphocytes concentrations do not differ significantly (p≤0.05). The results suggest that aqueous extract of Sorghum vulgare leaf sheath (at 800mg/kg) could be used in the treatment of hypertriglyceridemia and its related complications in murine models.

Keywords: Sorghum vulgare, hypertriglyceridemia, cardiovascular diseases.


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