Abstract
PLASMA LEVELS OF VON WILLEBRAND FACTOR ANTIGEN IN SUDANESE PREGNANT LADIES IN KHARTOUM 2017

Mohamed Hassan Mohamed Bilal* and Ibrahim Khedir Ibrahim

ABSTRACT

Von Willebrand factor (VWF) is a large sialoglycoprotein that circulates in normal plasma as a series of heterogeneous multimers and plays a critical role in primary hemostasis by mediating platelet adhesion to exposed collagen at sites of vascular injury. This is a cross sectional study conducted at Omdurman Maternity Hospital, Omdurman City to evaluate the vwf level among Sudanese pregnant womens. Forty apparent normal pregnant women recruited at the antenatal clinic were evaluated for VWF: Ag in platelet poor plasma using commercial ELISA kits from Technoclone Vienna, Austria .The data was analyzed using SPSS version 21. The result showed that there is no significant association between pregnancy and plasma vwf level (p-value=0.8) but the result show significant association between vwf and age (P-value=0.000). The mean vWF Ag level is within normal range in pregnancy however there is a insignificant decline in activity in the third trimester.

Keywords: Von Willebrand factor, pregnancy.


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