Abstract
PARTIAL THROMBOPLASTIN TIME AND PROTHROMBIN TIME AS INDICATORS OF HEMORRHAGIC RISK IN POSTOPERATIVE PATIENTS ON WARFARIN PROPHYLAXIS

Tawfig Ashoor Salem* and Mahdi Hussein Abdelrazig

ABSTRACT

Background: The partial thromboplastin time (PTT) or activated partial thromboplastin time is a performance indicator measures the efficacy of both the "intrinsic" (now referred to as the contact activation pathway) and the common coagulation pathways. Objective: This study aimed to assess Prothrombin Time and Activated Partial Thromboplastic Time in Postoperative Patients on Warfarin Prophylaxis as a risk factor of post-operative bleeding. Materials and Methods: This was a case-control study conducted in Khartoum, Sudan. It included 100 participants, (50 Sudanese Patients undergoing surgery who was taken prophylaxis warfarin as a cases, compared with 50 age and sex matched normal subjects as control). Prothrombin Time, Activated Partial Thromboplastic Time and INR levels were determined by Stago ® coagulometer. Results: Mean age of participants was 62 years, the majority 62% of them were females. Mean levels of APTT and PT among cases was (66±25) and (33±5) respectively, compared with (41±6) and (13±3) respectively, among controls. Both findings of APTT and PT differences revealed significant association between groups, (P=.000). postoperative bleeding was obtained in 17 (34%) of cases, and 4 (8%) of controls. Significant association revealed between groups; (P=.000). Conclusion: This study concluded that; PT and APTT were prolonged in Postoperative Patients on warfarin prophylaxis. So, PT and APTT levels were strongly affected by warfarin prophylaxis.

Keywords: PT, PTT, Warfarin Prophylaxis.


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