Abstract
DESIGN, SYNTHESIS AND EVALUATION OF BIOLOGICAL ACTIVITY OF AMIDE DERIVATIVES OF GRAMINE

Badvel Sreedhar, Thummaluru Veera Reddy, Kollu Umapriya, Chamarthi Naga Raju* and Gandi Vidya Sagar Reddy

ABSTRACT

A series of new amide derivatives of 3-(3-((dimethylamino)methyl)-1H-indol-1-yl)propanoic acid 2 were synthesized after converting 2 as its acid chloride 3 and reacting 3 with various bioactive amines using 1- methylimidazole as an acid scavenger by Schotten-Baumann reaction. The newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. The title compounds were evaluated for their efficacy as antioxidant and antimicrobial agents in vitro. The synthesized amides 4c and 4f exhibited promising antioxidant activity and compounds 4c-g showed high inhibitory activity against both bacteria and fungi.

Keywords: Gramine; 1-methylimidazole; Schotten-Baumann reaction; antioxidant and antimicrobial activities.


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