Pushpa A. Karale*, Mahesh A. Karale, Vishveshwar Dharashive, Shivkumar Ladde and Vidya Yelam


The aim of recent study was to estimate anti-inflammatory potential of methanolic extract of leaves of Sesbania grandiflora using animal model. The anti-inflammatory study of methanolic extract (SGME) was performed by using 200 mg/kg and 400mg/kg dose in carrageenan induced and formalin induced rat paw edema model. The phytochemical screening of extract also carried out as supportive study. Acute toxicity study was carried out to determine the dose and safety of extracts by using OECD guidelines. The indomethacin was used as standard drug for evaluation of anti-inflammatory potential. The phytochemical screening illustrated the presence of secondary metabolites such as alkaloids, glycosides, tannins, flavonoids, saponins. The result depicted that SGME showed remarkable anti-inflammatory potential in both doses in formalin induced rat paw edema and demonstrated maximum inhibition (400mg/kg) of paw edema after 24 hr (**P< 0.01). The oral administration of SGME at the doses 200 & 400 mg/kg demonstrated maximum inhibition at 24 hr in carrageenan induced paw edema. The SGME illustrated inhibition of paw edema in 1-2 hours of carrageenan and formalin induction. Therefore, we conclude that the anti-inflammatory potential of SGME may be due to inhibition of histamine, serotonins and kinins.

Keywords: Sesbania grandiflora, Anti-inflammatory, Carrageenan, Formalin.

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