Abstract
ASSESSMENT OF THE ANTIOXIDANT ACTIVITY OF QUERCUS INFECTORIA GALL EXTRACT AND ITS EFFICACY IN WOUND HEALING USING OPTICAL COHERENCE TOMOGRAPHY IN SWISS ALBINO MICE

Sunita Shukla*, Khageswar Sahu, Priyanka Sharma, Ankita Joshi and Deepak Bhatnagar

ABSTRACT

Use of medicinal plants for wound healing is widely accepted as it is economical with almost no side effects. Galls of Quercus infectoria (QI) used in medicinal preparations are known for their anti-inflammatory properties. However, the effect of application of the QI plant extract on wound healing is poorly understood. The QI gall extract in methanol was prepared by Soxhlet method and the major phytochemicals such as total phenol, total flavonoid and total triterpenoid were analyzed for their antioxidant properties. The QI was also converted in a form of a gel for tropical application. The wound healing property of this gel was evaluated in tape stripped wounds using Optical Coherence Tomography (OCT), a non invasive optical imaging technique for histological assessment of edema formation, epithelialization, granulation tissue deposition and epidermis thickness. Wound contraction was calculated from the photographs taken on different days. QI gel treated mice on day 2 showed reduced edema, higher amount of granulation and faster epithelialization by OCT and histology as compared to control. The epidermis thickness of the treated groups as observed from OCT and histology was ~2 fold more than that of untreated wounds as observed from OCT on day 9. The increase in the collagen synthesis with absence of inflammatory cells was also seen in wounds treated with QI extract. Further, compared to untreated significant wound contraction was observed in treated wounds. The results from OCT, histology and wound contraction studies provide evidence for the ethno medicinal use of QI gall extract for wound healing, which occurs probably due to the presence of major phytochemicals and the antioxidant activity of the extract.

Keywords: Polarization Sensitive Optical Coherence Tomography (PS-OCT), Optical Coherence Tomography (OCT) imaging, wound healing, Quercus infectoria.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • JULY ISSUE PUBLISHED

    JULY 2018 Issue has been successfully launched on 1 July 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT