Abstract
ANTIOXIDANT POTENTIAL OF BIOGENIC SILVER NANOPARTICLES FROM ANACARDIUM OCCIDENTALE LEAF IN DALTON’S ASCITES LYMPHOMA-BEARING SWISS ALBINO MICE

Madhubanti Bepari, Pralay Maity, Ananya Pradhan, Surya Kanta Dey and Dr. Sujata Maiti Choudhury*

ABSTRACT

Peroxidation of membrane lipids and oxidative damage of DNA and proteins are caused by free radicals and it is believed to be related to a variety of chronic pathological ailments such as cancer. The aim of this study was to evaluate the in vivo antioxidant potential of synthesized biogenic silver nanoparticles using aqueous extract of Anacardium occidentale leaf (AOAgNPs) in Dalton’s ascites lymphoma (DLA)-bearing Swiss albino mice. AOAgNPs was administered intraperitoneally at the dose level of 2 and 4mg/kg body weight/day for consecutive 14 days after 24 hours of cell inoculation (1×106 cell) to mice using 5-fluorouracil as standard drug. Treatment with AOAgNPs decreased the levels of hepatic and renal malondialdehyde (MDA), oxidized glutathione (GSSG) and increased reduced glutathione (GSH) level, the activities of catalase (CAT), super oxide dismutase (SOD) and peroxidases in DLA-bearing mice. The study reveals that AOAgNPs exhibit prominent antioxidant activities in Dalton’s ascites lymphoma-bearing Swiss albino mice.

Keywords: Silver nanoparticles; Anacardium occidentale leaf; Dalton’s ascites lymphoma; Antioxidant; Reduced Glutathione.


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