Abstract
SYNTHESIS, CHARACTERIZATION AND ANTI BACTERIAL ACTIVITY OF NEW 2-PYRIDONES, AMINO NICOTINATES FROM AROMATIC ALDEHYDES

Mamatha Kalyankar*, Dr. V. Jayathirtha Rao and Sridhar Thandra

ABSTRACT

Synthesis from aromatic aldehyde to new 2-pyridones as well as amino nicotinates by treating acetylated Baylis-Hillman esters and acetylated Baylis-Hillman nitriles with enamines via [3+3] annulation protocol and it yields well. It was characterized by spectroscopic techniques and screened their antibacterial activity. The compounds exhibit inhibitory effect on the growth of some bacteria of Gram positive and Gram negative are Bacillus substilis, Micrococcus luteus, salmonellatyphi, Escherichia coli by using standard drug Treptomycin and solvent DMSO. In this method provides highly efficient access to multi functionalized pyridine compounds, which are useful intermediates for further chemical manipulation leading to preparation of other functional group or pyridine fused heterocycles.

Keywords: Aromatic aldehyde, Baylis-Hillman reaction, antibacterial activity.


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