Abstract
EVALUATION OF CYTOTOXIC ACTIVITY OF CHORDA FILUM FROM THE LEBANESE COAST AGAINST MCF-7 CANCER CELL LINE

Mona Y. Tannoury*, Myriam Khayrallah, Antoine M. Saab, Mona Diab-Assaf, Francine Rizk, Aline Hamadé* and Fadia Najjar

ABSTRACT

The discovery of cancer drugs and the identification of agents that effectively destroy cancer cells or stop their growth without toxicity to normal cells, and reduce the opportunity for the development of drug resistance by cancer cells and reduce side effects would have an important impact on cancer therapy. Many studies have demonstrated the anti-cancer effect of natural materials from marine resources especially marine algae that elicit unique and unexpected biological activities. In this report, we investigated the cytotoxic activity of a crude extract from Chorda filum (Chordaceae), a marine brown algae collected from the Lebanese coast, against MCF-7 human breast cancer cell line using trypan blue exclusion test. This ethanol-acetone extract showed cytotoxic activity against MCF-7 cancer cell line with IC50 value of 15,373 μg/ mL after 48 hours of treatment. Further research designed to isolate and identify novel and efficient anticancer drug candidates from this seaweed extract need to be explored.

Keywords: brown algae; Chorda filum; cytotoxic activity; MCF-7; trypan blue exclusion test.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • APRIL ISSUE PUBLISHED

    APRIL 2018 Issue has been successfully launched on 1 April 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT