Abstract
THE EFFECT OF COMPETITIVE AND NONCOMPETIVE ANTAGONIST OF ASPARTATE ON THE SURVIVAL TIME OF MICE WITH EXPERIMENTAL TETANUS

Mujezinovic Indira, Smajlovic Ahmed, Katica Muhamed*, Gradascevic Nedzad and Dukic Behija

ABSTRACT

Tetanus is dangerous, infectious, noncontagious, acute and mostly afebrile illness of humans and different animal species, which is caused by Gram positive, ubiqutarious anaerobic Clostridium tetani. It produces a specific neurotoxin, which consists of two components: tetanospasmin and tetanolysin. Tetanospasmin is a component of tetanus toxin which actually leads to emergence of clinical signs. Mechanism of action of tetanus toxin is still unknown, but it is clear that the main target site is the spinal cord, where it blocks the release of inhibitory transmitters which results in domination of excitatory transmitters. In our experiment, we tried to normalize the disorders which are results of tetanus toxin action by applying indol-2-carboxylic acid (at doses of 5, 10, 20, 30 and 50 mg/kg b.w.) and to investigate its combination with ketamine (at dose of 10 mg/kg b.w.) and aminooxyacetic acid (at dose of 20 mg/kg b.w). Experiments were conducted on albino mice of both sexes. Experimental tetanus was induced by intramuscular application of tetanus toxin at a dose of 0.2 μg per animal. Application of substances in experimental groups was performed after the occurrence of local tetanus in right leg, approximately 24 hours after administration of tetanus toxin. Through our research, we found that indol-2-carboxylic acid had the best effect at a dose of 20 mg/kg b.w. Additionally, combination of indol-2-carboxylic acid with ketamine and aminooxyacetic acid had weak effect on the half time survival period in mice with experimental tetanus in the trial, as compared to the control group.

Keywords: Tetanus toxin, indol-2-carboxylic acid, ketamine, aminooxyacetic acid.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • APRIL ISSUE PUBLISHED

    APRIL 2018 Issue has been successfully launched on 1 April 2018

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 4.382 to 4.918 due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT