Abstract
REM SLEEP DEPRIVATION-INDUCED OXIDATIVE STRESS AND ITS ATTENUATION BY WITHANIA SOMNIFERA (L.) IN DISCRETE REGIONS OF RAT BRAIN.

Dr Ravindran Rajan*, Babukumar Mani, Annadurai Shanmuganathan, Saravanan Selvaraj, Prakash Selvaraj, Sakthivel Govindraj

ABSTRACT

Currently, plants are used as therapeutic agents in the wide range of clinical applications. The aim of this study is to assess the Antioxidant activity of Withania somnifera in 72 hours REM sleep deprivation. The plant (root) sample collected and Ethanolic extraction was done by using Soxhlet apparatus. Five groups of Wistar strain male albino rats were used in this study. Each group comprises of 6 rats and multiple platform models used for REM sleep deprivation. The values were statistically analyzed using one-way analysis of variance (ANOVA) followed by Tukey's posthoc test for multiple comparison methods. The Significance level was kept at P<0.05. The activity of Superoxide dismutase, Lipid peroxidation, Catalase, Glutathione peroxidase, levels of reduced glutathione, Vitamin C, Vitamin E in discrete regions of the rat brain and plasma Corticosterone level were measured. Withania somnifera possesses remarkable antioxidant activity by normalizing all the altered enzymes and plasma corticosterone level as a result of 72 hours REM sleep deprivation exposure.

Keywords: Antioxidants, Withania somnifera, REM sleep deprivation, oxidative stress and corticosterone.


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