Abstract
FORMULATION AND IN-VITRO EVALUATION OF TABLET CONTAINING IBUPROFEN AND COATED OMEPRAZOLE

Jayesh S. Baldota*, Ujwala Bagmar, Roshani Malpani and Nayan Mandora

ABSTRACT

The present study was carried out for development of fixed dose combination of ibuprofen and omeprazole in a single tablet. Ibuprofen and the omeprazole (coated with the Eudragit L100) are combined in a single tablet. The omeprazole was coated with Eudragit L 100 by solid dispersion method. Ibuprofen granules were prepared by wet granulation method. The formulation blends were subjected to various pre-formultion studies and were found to be good. The tablets were compressed and subjected to dissolution studies. The batch F3 shows better results and good dissolution.

Keywords: Ibuprofen, Omeprazole, Eudragit L 100, Solid dispersion, Tablet.


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