Abstract
MORICANDIA ARVENSIS CHLOROFORM EXTRACT INCREASES T-LYMPHOCYTE PROLIFERATION, SUPPRESSES NO PRODUCTION, AND AFFECTS CELL ANTIOXIDANT ACTIVITY IN VITRO

Ines Skandrani*, Mounira Krifa, Kamel Ghedira and Leila Chekir-Ghedira

ABSTRACT

Moricandia arvensis (Brassicaceae/crucifer) is a medicinal plant widespread in southern Tunisia. Despite its many uses in traditional medicine, there is no report addressing the effects of M.arvensis extracts on mice immune cell function. In this study, the immunomodulatory and anti-inflammatory activities of M. arvensis Chloroform root (ChlR) extract were investigated. The extract might act as modulator of cellular immune responses in situ by stimulating the proliferation of T-lymphocytes. On the contrary, ChlR extract inhibits LPS stimulated splenocytes proliferation, implying a potential inhibition of B-cells and thus the humoral immune responses. Without mitogens stimulation, ChlR extract enhances significantly cell proliferation and affects macrophage functions by modulating their lysosomal enzyme activity and nitric oxide release. Considerable antioxidant effects were also observed on the cellular antioxidant activity. Overall ChlR extract from M. arvensis enhanced cellular immune responses and exerted an anti-inflammatory effect fortifying the importance of the use of its products as anti-inflammatory agents.

Keywords: Moricandia arvensis, proliferation, splenocytes, immunomodulation, cellular antioxidant activity.


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