Abstract
SYNERGISTIC EFFECT OF IRVINGIA GABONENSIS AND PSIDIUM GUAJAVA LEAVES AGAINST DIARRHOEA CAUSING AGENTS.

Unaeze Bright Chukwuebuka*, Nwankpa Nwanneamaka Samuel, Ejike Chinwe Ebele and Onwuasoanya Uche Francisca

ABSTRACT

Synergistic combinations of antimicrobial agents with different mechanisms of action have been introduced as more successful strategies to combat infections involving diarrhoea. In this study, we investigated synergistic antimicrobial activities of Irvingia gabonensis and Psidium guajava leaves extracts which are commonly used plants with different antimicrobial agents. Antimicrobial susceptibility of some bacterial and fungi were tested against the combination of different ratios of I. gabonensis and P. guajava extracts. Minimum inhibitory concentrations (MIC’S) were determined by agar diffusion method. Plant extracts were tested for synergistic antimicrobial activities with different antimicrobial agents by checkerboard titration. In the results, the disc diffusion method showed synergistic effect between I .gabonensis and P. guajava against tested organisms. FIC value obtained by checkerboard assay showed less than 1 in combination, this indicating synergistic interaction between the two plants. The study suggest that the combination of the two plants could perform better in the management of diarrhoea than monotherapy.

Keywords: Diarrhoea, Synergistic effects, Irvingia gabonensis, Checkerboard assay, Psidium guajava.


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