Abstract
INFLUENCE OF GENISTIN ON ENERGY FORMATION, REACTIVE OXYGEN SPECIES AND OXIDASE SYSTEM ACTIVITY OF MITOCHONDRIAL MEMBRANE

B. A. Niyazmetov*, G. R. Abdullaev, Yu. A. Matyakubova and K. T. Almatov

ABSTRACT

Genistin dose-dependently increases ADP:O ratio in liver mitochondria. This process is especially noticeable in succinate oxidation. At low concentrations, genistin, does not affect on mitochondrial respiration, but with increasing of its concentration glutamate oxidation significantly decreases.Genistin inhibits lipid peroxidation and lytic enzymes activity in mitochondria. This means that genistin increasing bilayer membranes of mitochondria, stabilizes compactness of membranes. In this regard, cobra venom’s exogenous PLA2 availability obstructed to phospholipids of mitochondrial membranes.

Keywords: Genistin, liver, mitochondria, glutamate, succinate, ADP:O ratio, cobra venom, PLA2.


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