Amrita A. Singh*, Dr. Kantilal Narkhede and Dr. Sachin Narkhede


Hypertension is one of the serious disease which leads to stroke, congestive heart failure and ultimately leads to death world-wide. The Hypertension is not treated efficiently by single drug thus combination of drug is used for the treatment of Hypertension called single pill combination therapy. Most of the heart patient get die during sleep time between 3 AM to 5 AM due to heart failure which occur due to Hypertension thus to treat the disease at the time when it is at peak, Chronotherapeutic drug delivery system is used which will release the drug in early morning after consuming the dosage form at night time that is after suitable lag time. Various Techniques are used for getting the lag time in Chronotherapeutic drug delivery system like time controlled, stimuli controlled and externally controlled by magnet etc. various dosage form is prepared like core in cup tablet, compression coated tablet. The development of single pill combination in chronotherapy leads to various advantages like decrease in dose of the drug which will leads to decrease side effect, increase patient compliance, disease is treated efficiently.

Keywords: Hypertension, Chronotherapy, single pill combination therapy.

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